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Thursday, 03.11.2010, 10:21pm (GMT-7)
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Allele Granted Broad Patent on RNAi in China ; Which fluorescent protein is the best FRET donor? ; Allele Will Receive Its 3rd US Patent On RNAi ; Allele Biotech Pre-Announces its Product Line in iPSC Creation Using Baculoviral Vectors ; Biotech Companies Can Now Make Company News Releases Through AlleleNews
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Allele Granted Broad Patent on RNAi in China
Thursday, 02.11.2010, 10:48am

Allele Biotechnology & Pharmaceuticals, a San Diego based private company with associate offices and laboratories in China and distribution channels in 30 countries, was granted a major landmark patent in China in the field of RNA interference (RNAi). 

Which fluorescent protein is the best FRET donor?    Allele Will Receive Its 3rd US Patent On RNAi
 
 
Allele News Release
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Allele Biotech Pre-Announces its Product Line in iPSC Creation Using Baculoviral Vectors
Monday, 11.16.2009, 02:12pm
As a new approach of establishing novel product lines and generating feedbacks and potential interests early on, Allele Biotech has started disclosing its intended/ongoing research plan on AlleleBlogs or through AlleleNews.
Biotech Companies Can Now Make Company News Releases Through AlleleNews
Allele Biotech Receives Funding from the National Cancer Institute (NCI) to Produce Cancer Antigens
   
News Release from Other Companies
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New Randox Life Science Website up and running!
Thursday, 03.11.2010, 10:17am
FW: Randox press release - New Randox Life Science Website

Randox Life Sciences is proud to announce the launch of its new and improved website.  The new look site is easy to navigate and allows customers to purchase any of life science products online  Please find attached the press release along with our logo and a screen shot of the new website.  I would be most grateful if you would consider us for inclusion in your publication. 

How I started my company and why--Inaugural Event by San Diego Entrepreneurs Exchange (SDEE)
News Release from Randox--NEW Liquid quality control sera available now
All science fields
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PTH battles TGF-β in bone
Wednesday, 03.10.2010, 12:31am
Bone remodelling in vertebrates is coordinately regulated by the opposing effects of parathyroid hormone (PTH) and transforming growth factor-beta (TGF-β). PTH couples the processes of bone resorption and formation by enforcing simultaneous internalization of TGF-β type II receptor (TβRII) and PTH type 1 receptor (PTH1R), which attenuates both TGF-β and PTH signalling in vivo.
Cell type–specific gene expression differences in complex tissues
Quick thinking: perceiving in a tenth of a blink of an eye
   
Allele-Relevant Journal Publications
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Baculovirus used to make flu vaccines in insect cells
Thursday, 01.07.2010, 10:53am

The vaccines were produced much more quickly than the current method using eggs.  Insect cell system also provides less allergy effects and better overall safety.

Publication by Allele Scientists: A Tale of Twin Functions
Ai HW, Henderson JN, Remington SJ, Campbell RE.
iPS Stem Cells
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iPS patent issues in the spotlight
Friday, 02.05.2010, 12:56pm

UK grants patent for iPS cells to a Japanese research group…but not Yamanaka!  US allows iPS cells to an American lab…but not Thomson!

Nature Method's review on iPSCs and lists Allele Biotech as a supplier
Reprogrammable mice created by a single insertion of polycistonic iPS factors
   
Camelid Antibodies
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Two affinity peptides linked as high affinity binders as “Synbody”
Tuesday, 01.19.2010, 09:41am
Selecting for high affinity and specificity binding molecules such as antibodies, aptamers, or antibody fragments/equivalents is a demanding process and any major progress should almost certainly result in interest from pharmaceutical companies looking for new drug candidates.
Immunoprecipitation Using GFP-Trap Identified Missing Structure-Specific Nucleases for DNA Repair in Human
Intracellularly Expressed Camelid Single-Domain Antibody (VHH) Counteracts Cytotoxicity Seen in Agricultural Epidemics
RNAi Updates
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MicroRNAs: From Decay to Decoy, and beyond
Tuesday, 03.09.2010, 09:41am
MicroRNAs interact with Argonaute proteins to guide posttranscriptional gene silencing. Eiring et al. (2010) now show that miR-328 has a second function, acting as a decoy by binding to hnRNP E2 and lifting its translational repression of an mRNA involved in myeloid cell differentiation. (Cell)
Silicon Nanowires to Penetrate Cell Membrane for TransfectionSilicon Nanowires to Penetrate Cell Membrane for Transfection
New RNAi delivery technology demonstrates higher efficacy and decreased dosage requirements
   
FP Technology
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BioTechnique: Recent papers advance GFP knowledge
Wednesday, 11.18.2009, 02:48pm

A coveted mainstay in any life-sciences toolbox, green fluorescent protein (GFP) has replaced many dyes in biological studies because it is non-toxic and can function as a reporter of expression when attached to a gene of interest.

How to use photoconvertible fluorescent proteins to trace dynamic subcellular structures
Lab Visits/Vendor Shows
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Holiday Season Vendor Show at Salk This Tuesday!
Monday, 12.21.2009, 10:58am
We started 2009's vendor show series at Salk, it would be only appropriate to also complete it there, one of favorite places!   Check our our new products, new look, and new sales person--introducing Christiiiiiiiiiiiiiiiina!  Go say hello to her and give her some encouragement while enjoying food and coffee!
Breakfast at ACADIA Pharmaceuticals went very well
Sep 1st Vendor Show at Pac Hall
   
Metabolism & Diabetes
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Genome-wide association study (GWAS) of metabolic traits identified metabolically relevant enzymes or carriers.
Monday, 01.18.2010, 01:39pm
By measuring 163 metabolite concentrations and ratios in serum and use them as metabolic traits, SNPs were identified that provided what Illig et al. called “genetically determined metabotypes”.
 
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Want to use FP as tag to see low level expression or in an acidic cellular environment? Use mTFP1 or mWasabi and get pictures like this…
mWasabi-protein tyrosine kinase 2
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::| Hot News
Allele Biotech Pre-Announces its Product Line in iPSC Creation Using Baculoviral Vectors
Biotech Companies Can Now Make Company News Releases Through AlleleNews
Allele Biotech Receives Funding from the National Cancer Institute (NCI) to Produce Cancer Antigens
Allele Annouces New Products Based on Camelid Antibodies