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Friday, 09.03.2010, 01:24am (GMT-7)
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Generation of Functional Heart Cells by Direct Programming ; MicroRNA-132 is identified as a stimulator of neovascularization ; Monomeric Photoconvertible Fluorescent Protein for Imaging of Dynamic Protein Localization ; More Naïve State of Human iPSCs? ; Oct3/4 Promoter Blocks Cancer Stem Cells from Differentiation—Potential for Stably Supplying CSCs
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Generation of Functional Heart Cells by Direct Programming
Tuesday, 08.17.2010, 09:59am

Transduction of 3 cardiomyocyte-specific genes into cardiac fibroblasts reprogrammed them into cardiomyocytes, a process that one day could be used to heal heart lesions.

MicroRNA-132 is identified as a stimulator of neovascularization    Monomeric Photoconvertible Fluorescent Protein for Imaging of Dynamic Protein Localization
 
 
Allele News Release
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House's Appropriations Committee’s health spending subcommittee's 2011 NIH NSF budgets
Friday, 08.06.2010, 11:07am
The $32.23 billion NIH budget represents an increase of 3.2% over fiscal year (FY) 2010, and the $7.4 billion NSF budget reflects an 8% increase over FY 2010.
Breast Cancer Gene Patents Invalidated
Allele Granted Broad Patent on RNAi in China
   
News Release from Other Companies
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Improved patient profiling with Randox Metabolic Syndrome Arrays
Wednesday, 08.11.2010, 04:55pm

The Metabolic Syndrome Arrays from Randox offer simultaneous determination of analytes associated with Metabolic Syndrome and related disorders for improved patient profiling.

Accurately and efficiently monitor the performance of HbA1c assays
Witness the launch of Evidence Evolution at AACC
All science fields
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Spontaneous network activity visualized by ultrasensitive Ca2+ indicators, yellow Cameleon-Nano
Thursday, 09.02.2010, 04:11pm
Engineering of the Ca2+-sensing domain in existing yellow Cameleon Ca2+ indicators is used to create indicators with a range of increased Ca2+ affinities capable of detecting subtle changes in intracellular Ca2+ at low resting levels.
Focusing on Autophagy
The call of the human proteome
   
Allele-Relevant Journal Publications
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From Nature Biotechnology: SBIR grants wax
Friday, 06.18.2010, 08:15am
Awards under the Small Business Innovation Research (SBIR) program have just been given a boost. As of March 30, the cap for SBIR phase I awards has risen from $100,000 to $150,000, and for phase II awards from $750,000 to $1,000,000.
Baculovirus used to make flu vaccines in insect cells
Publication by Allele Scientists: A Tale of Twin Functions
iPS Stem Cells
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More Naïve State of Human iPSCs?
Friday, 06.25.2010, 12:13pm
Using Oct3/4, Sox2, Klf4, cMyc, and Nanog on lentiviral vectors together and in the presence of LIF, human iPS cells can be generated that behave much more like mouse iPS cells...
Oct3/4 Promoter Blocks Cancer Stem Cells from Differentiation—Potential for Stably Supplying CSCs
Mouse induced pluripotent stem cells (iPSCs) differ from embryonic stem cells with aberrant silencing of imprinted genes on chromosome 12qF1
   
Camelid Antibodies
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GFP-Trap Successfully Used in Plants and Other Systems
Monday, 07.26.2010, 09:44am
Latest list of papers reporting use of Camelid Antibody-based GFP-Trap.
Two affinity peptides linked as high affinity binders as “Synbody”
Immunoprecipitation Using GFP-Trap Identified Missing Structure-Specific Nucleases for DNA Repair in Human
RNAi miRNA Updates
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Fruitless chirping in the night
Thursday, 07.08.2010, 08:43pm
By injecting double-stranded RNA into the abdomen of male cricket, the gene that controls species barrier for reproduction was identified.
Intronic miRNA and host gene coordinate to regulate biological process (cholesterol hoemostasis)
Increasing siRNA transfection by thiol modifications
   
FP Technology
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Whole mouse organs imaged in 3D Using Self Fluorescence
Monday, 07.05.2010, 05:48pm
Using enhanced fluorescence microscopy techniques without damaging the organ by slicing or sampling.
Super-Imaging, Defy the Light Diffraction Limit
Which fluorescent protein is the best FRET donor?
Lab Visits/Vendor Shows
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Hello SDSU
Tuesday, 08.03.2010, 01:48pm
Last Friday (July 30th) Allele Biotech hosted a breakfast table at San Diego State University in the Life Sciences building. 
Great Introduction of Allele Services at LIAI
SCRIPPS INSTITUTION OF OCEANOGRAPHY, UC SAN DIEGO Vendor Show
   
Metabolism & Diabetes
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Genome-wide association study (GWAS) of metabolic traits identified metabolically relevant enzymes or carriers.
Monday, 01.18.2010, 01:39pm
By measuring 163 metabolite concentrations and ratios in serum and use them as metabolic traits, SNPs were identified that provided what Illig et al. called “genetically determined metabotypes”.
 
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Want to use FP as tag to see low level expression or in an acidic cellular environment? Use mTFP1 or mWasabi and get pictures like this…
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::| Hot News
More Naïve State of Human iPSCs?
Oct3/4 Promoter Blocks Cancer Stem Cells from Differentiation—Potential for Stably Supplying CSCs
Super-Imaging, Defy the Light Diffraction Limit
Intronic miRNA and host gene coordinate to regulate biological process (cholesterol hoemostasis)
Mouse induced pluripotent stem cells (iPSCs) differ from embryonic stem cells with aberrant silencing of imprinted genes on chromosome 12qF1
Sox2 and Oct4 are the “Master Regulators" of Stem Cells
Allele Granted Broad Patent on RNAi in China
Which fluorescent protein is the best FRET donor?
Allele Will Receive Its 3rd US Patent On RNAi
Allele Biotech Pre-Announces its Product Line in iPSC Creation Using Baculoviral Vectors