Lab Visits Please email our sales representatives to schedule lab visits in your area.
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05.16.08
Allele is proud to take part of the recent vendor show organized by the Scripps Research Institute in La Jolla . We had a chance to demonstrate our new All ele Equip lab equipment product line, designed by engineers with wet lab experience to be small, convenient, and at low cost. We also showcased many other new products, miniprep kits, PCR purification kits, etc. Thank you all for your suggestions given at and after the show. For those who have requested free sample from us, please give us your feedback, we always listen!
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04.28.08
We here at Allele would like to thank all of the various individuals at Burnham for allowing us to display to them the new and exciting research and development taking place at Allele. Around 80 people took their time to stop by and register at our table. Once again we would like to convey our gratitude for this and we will be sending out the various gifts and samples we promised as soon as possible.
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| Latest Publication |
Shaner NC, Patterson GH, Davidson MW
Advances in fluorescent protein technology.J Cell Sci. 2007 Dec 15;120(Pt 24):4247-60.
Development of new and improved fluorescent proteins (FPs) has been ongoing at blinding speed, resulting in enhanced photostability, reduced oligomerization, faster maturation rate, and insensitivity to pH. Despite the recent advances in FP technology, most researchers still use the enhanced version of Aequorea victoria jellyfish wild-type GFP (EGFP), and the original cyan and yellow derivatives (ECFP and EYFP), for most imaging applications. This review addresses frequent misconceptions during transition to new FP choices.
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Hui-wang Ai , Scott G. Olenych , Peter Wong , Michael W. Davidson and Robert E. Campbell .
Hue-shifted monomeric variants of Clavularia cyan fluorescent protein: identification of the molecular determinants of color and applications in fluorescence imaging.BMC Biol. 2008 Mar 6;6(1):13.
Site-direct and random mutagenesis in combination with library screening was employed by the creators of mTFP1 to develop new colors of mTFP1-derived monomeric FPs. The techniques described here are truly state-of-art in FP evolution and can be applied to other protein variation studies. It should be an enjoyable read for researchers in many fields.
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Ai HW, Henderson JN, Remington SJ, Campbell RE.
Directed evolution of a monomeric, bright, and photostable version of Clavularia cyan fluorescent protein: structural characterization and applications in fluorescence imaging. Biochem J. 2006 Dec 15;400(3):531-40.
This was the first publication on the designing and characterization of mTFP1 and its related fluorescent proteins.
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Shaner NC, Steinbach PA, Tsien RY.
A guide to choosing fluorescent proteins. Nature Methods 2005 Dec;2(12):905-9.
This review summarizes the properties of reported fluorescent proteins and their applications.
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Ni YH, Guo XR, Chen RH, Wang B, Zhang M, Fei L, Pan XQ, Guo M, Wang J.
(2007) A Novel Adipogenesis Factor Acting Upstream of PPAR? and C/EBP? is Abundant in Adipose Tissues and Over-expressed in Obese Patients. (In preparation).
This publication will report our discovery of a novel human factor with potential influence in fat cell development. It was a result from joint efforts between Allele scientists and an academic lab at the Nanjing Medical University during profiling of adipocyte differentiation related gene expressions. Additional factors from the same screen will be reported separately.
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Chen J, Wang L, Boeg YS, Xia B, Wang J.
(2002) Differential dimerization and association among resistin family proteins with implications for functional specificity J Endocrinol. 175(2):499-504.
This paper describes biochemical studies by Allele scientists and postdoctoral fellows on a family of obesity and diabetes related hormones, resistin proteins. It demonstrated the potential for functional multimerization and crosstalk among resistin molecules.
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