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Leukocyte Oxidative BurstA complete reagent kit for the quantification of oxidative leukocyte burst in whole blood samples using Flow Cytometry. Oxidative burst, or the rapid release of reactive oxygen species from cells, is used to degrade internalized particles and bacteria. Cells are incubated in stimuli to promote oxidative burst, intracellular fluorescence is measured to characterize leukocyte burst activity. Work Flow Publications
Low production of reactive oxygen species in granulocytes is associated with organ damage in systemic lupus erythematosus. Anders A Bengtsson, Åsa Pettersson, Stina Wichert, Birgitta Gullstrand, Markus Hansson, Thomas Hellmark, Åsa CM Johansson Chronic granulomatous disease |
IndicationsOxidative burst activity can be influenced by a number of genetic and acquired conditions, such as:
Additionally leukocyte burst can be depressed in neonatal or geriatric patients. The PhagoBurst test enables the precise monitoring of burst activity to clearly determine an individuals current state. Advantages
Oxidative Burst in CGD PatientsThe PhagoBurst Test is an excellent tool for diagnosing Chronic Granulomatous disease as well as X-linked carriers. I provides health practitioners with an additional dimension of sample data other imunodiagnositc tests cannot provide. As illustrated below, patients can have adequate phagocytic activity with severely reduced oxidative burst activity. Phagocytic Activity Oxidative Burst Activity |
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