Animal ID:
RB2033/2034
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Host:
Rabbit
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Reactivity:
Human
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Buffers:
Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column and eluted out with both high and low pH buffers and neutralized immediately after elution then followed by dialysis against PBS.
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Storage:
Maintain refrigerated at 2-8ºC for up to 6 months. For long term storage store at -20ºC. Avoid repeated freeze-thaw cycles.
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Application:
Tested by peptide-specific ELISA (1:1,000). IHC (1:50 ~1:100)
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Immunogen:
KLH conjugated synthetic peptide comprised of amino acids 409 - 423 [WVFKDNNVEEGYPRP] of the human matrix metalloproteinase 17 (MMP17) protein. |
Accession number:
NM_016155 |
Description:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Matrix metalloproteinase 17 (MMP17) is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, MMP17 is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. MMP17 activates pro-MMP-2 by cleavage but its precise biological function remains to be elucidated. |
Alternative Name(s):
matrix metalloproteinase 17, MT4-MMP, membrane-type matrix metalloproteinase 4, MMP17 |
References:
- Itoh Y, Kajita M, Kinoh H, Mori H, Okada A, Seiki M: Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase. J. Biol. Chem. 274(48): 34260-34266 (1999).
- Puente XS, Pendas AM, Llano E, Velasco G, Lopez-Otin C: Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma. Cancer Res. 56(5): 944-949 (1996).
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For Research Use Only. Not for Diagnostic or Therapeutic Use.
Purchase does not include or carry any right to resell or transfer this product either as a stand-alone product or as a component of another product. Any use of this product other than the permitted use without the express written authorization of Allele Biotech, Inc. is strictly prohibited |
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